Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080



Turkish Journal of Vascular Surgery 2008 , Vol 17 , Issue 2
Semptomatik ve Asemptomatik Hastalarda Karotid Arter Aterom Plak İçeriğinin Karşılaştırılması
Mete Burak ÖZDEMİR1, Caner ARSLAN2, Adnan Taner KURDAL1, Mine DEMİRBAŞ1, Pınar ATUKEREN3, Ahmet Kürşat BOZKURT1
1Kalp ve Damar Cerrahisi AD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, İstanbul
2Kalp ve Damar Cerrahisi Kliniği, TDV 29 Mayıs Hastanesi, İstanbul
3Biyokimya AD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, İstanbul
Objective: Homocystein, von Willebrand factor (vWF), fibrin and C-reactive protein (CRP) values were measured in carotid artery plaques from symptomatic and asymptomatic patients with carotid stenosis. The values were evaluated between groups. Material and Methods: 36 patients who underwent carotid endarterectomy, aged 54 to 77 (mean age: 64.16, 23 male, 13 female) were included in the study. 20 of them were symptomatic, 16 asymptomatic. Homocystein, fibrin, vWF, CRP were measured from samples taken from carotid plaques converted into supernatant. SPSS for Windows 10.0 programme was used for statistical analysis. P value less than 0.05 was accepted significant. Results: Homocystein value in symptomatic patients was 4.036±1.19 μmol/L, in asymptomatic patients, was 3.647±0.772 μmol/L (p=0.519). Fibrin value in symptomatic patients was 227.54±38.81 mg/dl, in asymptomatic patients, was 88.26±5.93 mg/dl (p<0.001). vWF in symptomatic group was 59.33%± 9.13%, in asymptomatics, was 42.83%±5.33% (p<0.001). CRP in symptomatic group was 0.33±0.13 mg/dl, in asymptomatics, was 0.26± 0.091 mg/dl (p=0.033). Differences in parameters, except for homocystein, were statistically significant. Conclusion: There was no relation between homocystein level an symptomatology. Amount of fibrin in the carotid artery atherosclerotic plaques increases with hemorrhage that may cause critical stenosis and disrupt plaque and so cause microemboli. Modification of the mentioned factors can change the progress of the disease. Keywords : Carotid artery stenosis, homosistein, vWF, Fibrin, CRP
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