Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080


Turkish Journal of Vascular Surgery 1996 , Vol 5 , Issue 3
The Effects of Clostridıopeptidase A on Venous Ulcers
A. A. Kürşat BOZKURT1, Cengiz KÖKSAL1, Güven ERDOĞ1
1İ.Ü. Cerrahpaşa Tıp Fakültesi, Göğüs Kalp ve Damar Cerrahi Anabilim Dalı, İsatanbul Venous ulceration is a well-known problem which effects almost 1-2 % of the population. The mainstay of the therapy is relieving of the venous hypertension with external compression and local wound care.

In this study 20 patients with venous ulceration were assigned into two groups. in the first group, elastic com­ pression and wet draping were used and in the other group clostridiopeptidase A with elastic compression were used and the healing effect of clostridiopeptidase A on venous ulcers were evaluated.

In the elastic compression and wet draping group, 8 of the 1O ulcers were healed during the study period of up to 6 months (mean 151.5). in 2 patients venous ulcers were persisted by the end of the study. in the elastic com­ pression and clostridiopeptidase A group, complete healing of all ulcers were observed during the study period (mean 103.5, p 0.05).

Specific affinity tor natural collagen and painless debridement makes the clostiridiopeptidase A and elastic co­ pression combination an effective therapeutic modality in venous ulcers. Keywords : Venous ulceration, Clostridiepoptidase, compression therapy