Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080


Turkish Journal of Vascular Surgery 2019 , Vol 28 , Issue 3
Evaluation of oxidative and antioxidant markers in the blood samples of patients with abdominal aorta pathology
Fevzi Sarper Türker1, Mine Erişir2
1Department of Cardiovascular Surgery, Elazığ Fethi Sekin City Hospital, Elazığ, Turkey
2Department of Biochemistry, Fırat University Faculty of Veterinary Medicine, Elazığ, Turkey
DOI : 10.9739/tjvs.2019.424 Objectives: This study aims to investigate the effects of oxidative damage on the development of the disease in patients scheduled for surgery for aortoiliac occlusive disease (AOD) and abdominal aortic aneurysm (AAA).

Patients and methods: Between June 2015 and July 2016, a total of 24 patients (22 males, 2 females; mean age 63.2±10.4 years; range, 41 to 76 years) who admitted to our clinic for surgery were included in the study. The study group consisted of all elective AOD and AAA patients. The control group (n=100) consisted of healthy volunteers including health care personnel, particularly physicians working in the hospital. We obtained blood samples before surgery and compared levels of malondialdehyde (MDA) as an indicator of oxidative damage, and the levels of certain antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) with the blood levels of healthy volunteers.

Results: The comparison of the patient and healthy volunteer groups showed that blood MDA levels increased due to the oxidative damage (p=0.001). Regarding the antioxidant activity, we found that GSH levels increased in the patient group; however, the SOD activity remained unchanged. The CAT activity was statistically significantly decreased in the patient group (p=0.001).

Conclusion: The increased oxidative damage levels (MDA) in all patient groups compared to healthy individuals may indicate that oxidative stress has an important role in the development of the disease. In the light of these results, we conclude that the GSH activity is not sufficient to compensate the existing damage and the low CAT activity in all groups may show that it has a role in the development of the disease. Keywords : Abdominal aortic aneurysm, aortoiliac occlusive disease, catalase, malondialdehyde, superoxide dismutase