Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080


Turkish Journal of Vascular Surgery 2019 , Vol 28 , Issue 3
Effects of mesenchymal stem cells to prevent adhesions for vascular reoperations: An experimental study
Mehmet Kabalcı1, Mehmet Zengin2, Nuray Bayar Muluk3, Üçler Kısa4
1Department of Cardiovascular Surgery, Medicine Faculty of Kırıkkale University, Kırıkkale, Turkey
2Department of Pathology, Medicine Faculty of Kırıkkale University, Kırıkkale, Turkey
3Department of Otorhinolaryngology Head and Neck Surgery, Medicine Faculty of Kırıkkale University, Kırıkkale, Turkey
4Department of Biochemistry, Medicine Faculty of Kırıkkale University, Kırıkkale, Turkey
DOI : 10.9739/tjvs.2019.560 Objectives: In the present study, we aimed to investigate whether mesenchymal stem cells (MSCs) were useful to reduce cutaneous adhesions, particularly for vascular reoperations.

Materials and methods: In this experimental study, 12 adult male Wistar Albino rats were used. In Group 1 (n=2, negative control group), no incision was performed. In Group 2 (n=5, positive control group), skin and subcutaneous tissues were incised. In Group 3 (n=5, MSC group), skin and subcutaneous tissues were incised and 3×106 MSCs were applied. Macroscopic scoring of adhesion and histopathological scoring of tissue repair response were evaluated.

Results: Macroscopic view of the adhesion values (Padjusted <0.0175), histopathological evaluation values (histiocytic response, vascularization, and granulocytic response and total response) (Padjusted <0.0175), and collagen deposit values (Padjusted <0.0175) of Group 3 were significantly lower than Group 2.

Conclusion: Our study results suggest that the use of MSCs seems to be useful to prevent adhesion formation in cutaneous injuries and that MSCs promote wound healing without adhesions in the experimental setting. Keywords : Adhesions, cutaneous, mesenchymal stem cells, rat, vascular reoperations