Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080

Turkish Journal of Vascular Surgery 2020 , Vol 29 , Issue 3
The effect of deep venous thrombosis on oxidative damage and vitamin A and beta-carotene levels
Fevzi Sarper Türker1, Ayşe Malbora2, Mine Erişir3
1Department of Cardiovascular Surgery, University of Health Sciences, Elazığ Training and Research Hospital, Elazığ, Turkey
2Department of Physiotherapy and Rehabilitation, Bitlis Eren University, Health High School, Bitlis, Turkey
3Department of Biochemistry, Fırat University Faculty of Veterinary Medicine, Elazığ, Turkey
DOI : 10.9739/tjvs.2020.593 Objectives: This study aims to investigate the effect of deep venous thrombosis (DVT) on oxidative damage, vitamin A, and beta-carotene levels.

Patients and methods: A total of 50 DVT patients (29 females, 21 males; mean age 48 years; range, 20 to 75 years) who were admitted to the cardiovascular surgery clinic of Elazığ Training and Research Hospital with acute (<2 weeks) or chronic (≥4 weeks) DVT and 100 healthy individuals (54 females, 46 males; mean age 46 years; range, 16 to 69 years) between January 2018 and July 2018 were included. Malondialdehyde, vitamin A, and beta-carotene levels in plasma of peripheral blood samples were analyzed.

Results: Demographic characteristics of the acute and chronic DVT patients were similar (p>0.05). In all DVT patients having thrombosis in the distal and proximal leg veins, the mean malondialdehyde (MDA) levels significantly increased and the mean levels of vitamin A significantly decreased, compared to healthy controls (p<0.05). No significant difference was found in vitamin A levels and demographic characteristics between acute and chronic DVT patients (p>0.05).

Conclusion: Our study results suggest that decreased vitamin A levels may play a role in the development of DVT. Keywords : Beta-carotene, deep venous thrombosis, malondialdehyde, oxidative stress, vitamin A

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