Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080



Turkish Journal of Vascular Surgery 2021 , Vol 30 , Issue 1
The effect of mean platelet volume-to-lymphocyte ratio on symptom onset in patients with carotid artery stenosis
Burak Erdolu1, Mesut Engin2
1Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, Turkey
2Department of Cardiovascular Surgery, University of Health Sciences, Mehmet Akif Inan Training and Research Hospital, Şanlıurfa, Turkey
DOI : 10.9739/tjvs.2021.809 Objectives: In this study, we aimed to investigate the effect of mean platelet volume-to-lymphocyte ratio (MPVLR) on symptom onset in patients with moderate carotid artery stenosis (CAS).

Patients and methods: Between January 2016 and January 2018, a total of 294 patients (178 males, 116 females, mean age 57.9±9.1 years; range, 44 to 81 years) diagnosed with moderate CAS were retrospectively analyzed. The patients were divided into two groups according to their symptomatology as Group 1 (n=238) including asymptomatic patients and Group 2 (n=56) including symptomatic patients. The diagnosis of CAS was made using carotid angiography. The degree of stenosis was determined. The MPVLR was evaluated.

Results: The mean age was 53.6±8.5 years in Group 1 and 64.9±9.7 years in Group 2 (p<0.001). In the multivariate analysis, advanced age (odds ratio [OR]: 1.235, 95% confidence interval [CI]: 1.204-1.738, p=0.012), hypertension (OR: 1.030, 95% CI: 1.007-1.552, p=0.037), and MPVLR (OR: 2.156, 95% CI: 1.932-3.116, p=0.005) were found to be independent predictors of the symptom onset. The receiver operating characteristics analysis revealed that the cut-off value for MPVLR was 5.48 (area under the curve [AUC]=0.694, 95% CI: 0.563-0.806, p=0.008) with 69.7% sensitivity and 51.2% specificity.

Conclusion: Our study results show that the high MPVLR value, which is a cheap parameter that can be calculated easily, can be used as a promising parameter of CAS symptoms for clinicians. Keywords : Carotid artery stenosis, cerebrovascular event, lymphocyte, mean platelet volume

Viewed : 233
Downloaded : 156