Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080



Turkish Journal of Vascular Surgery 2021 , Vol 30 , Issue 1
Is it possible to estimate the mortality risk in acute pulmonary embolism by means of novel predictors? A retrospective study
Ekrem Aksu1, Abdullah Sökmen1, Gülizar Sökmen1, Hakan Güneş1, Nurhan Atilla2, Bülent Güneri4, Adem Doğaner3, Mehmet Kirişci3, Murat Kerkutluoğlu1, Bayram Öztürk1, Erdinç Eroğlu5
1Department of Cardiology, Kahramanmaraş Sütçü Imam University, Faculty of Medicine, Kahramanmaraş, Turkey
2Department of Chest Diseases, Kahramanmaraş Sütçü Imam University, Faculty of Medicine, Kahramanmaraş, Turkey
3Department of Biostatistics, Kahramanmaraş Sütçü Imam University, Faculty of Medicine, Kahramanmaraş, Turkey
4Department of Orthopedics and Traumatology, Kahramanmaraş Sütçü Imam University, Faculty of Medicine, Kahramanmaraş, Turkey
5Department of Cardiovascular Surgery, Kahramanmaraş Sütçü Imam University, Faculty of Medicine, Kahramanmaraş, Turkey
DOI : 10.9739/tjvs.2021.836 Objectives: This study aims to evaluate the relationship of echocardiographic measurements, whole blood viscosity, and other hematological markers with short-term (0-30 days after the diagnosis) and long-term (31st day -12th month after the diagnosis) mortality in acute pulmonary embolism (APE).

Patients and methods: This retrospective study included a total of 80 patients (35 males, 45 females; mean age 68.0±17.1 years; range, 22 to 92 years) with the definitive diagnosis of APE between January 2015 and December 2017. The patients were divided into three study groups as follows: short-term mortality group (n=20; 25.0%), long-term mortality group (n=15; 18.8%), and alive group (n=45; 56.2%) surviving beyond one year during follow-up. The demographic data, Pulmonary Embolism Severity Index, simplified Pulmonary Embolism Severity Index, complete blood count, N-terminal pro-brain natriuretic peptide (NT-proBNP), D-dimer, C-reactive protein, whole blood viscosity values, and echocardiographic measurements of the patients were recorded.

Results: The increased levels of high shear rate-whole blood viscosity, low shear rate-whole blood viscosity, and the decreased levels of tricuspid annular plane systolic excursion were found to be associated with short-term mortality in APE. The red blood cell distribution width and NT-proBNP levels and pulmonary artery and right ventricular diameters were found to be associated with early and late mortality.

Conclusion: Whole blood viscosity levels appear to estimate the patients susceptible to early mortality in APE, while late mortality seems to be predictable in the presence of increased red cell distribution width. Echocardiographic measurements seem to be applicable indicators of increased early and late mortality in APE. Keywords : Acute pulmonary embolism, long-term mortality, short-term mortality, whole blood viscosity

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