Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080

Turkish Journal of Vascular Surgery 2013 , Vol 22 , Issue 1
Derin Ven Trombozlu Hastalarda Faktör V Leiden Mutasyonu Taraması ve Sonuçları
Olcay Murat DİŞLİ, Barış AKÇA, Köksal DÖNMEZ, Cengiz ÇOLAK, Hasan Berat CİHAN, Bektaş BATTALOĞLU, Nevzat ERDİL
1Kalp Damar Cerrahisi AD, İnönü Üniversitesi Tıp Fakültesi, Malatya DOI : 10.9739/uvcd.2012-32287 Objective: In this study, we aimed to investigate incidence of Factor V Leiden mutation in patients with deep vein thrombosis. Material and Methods: Between January 2009 and August 2011, 53 patients with deep vein thrombosis were investigated for Factor V Leiden mutation. Of all, 50.94% patients were males and age range was 19-83 years. All of the patients were hospitalized. Standard IV heparine and warfarine were administered. Screening tests for etiology were done for all patients. Results: Eleven patients were heterozygotes (7 males, 4 females) (20.75%), 2 patients were homozygotes (2 females) (%3.77). Pulmonary embolism was evident in 1 heterozygote female patient. Of 6 patients with recurrent deep vein thrombosis, 1 heterozygote male and 1 homozygote female patients were detected. One of the patients with reccurent deep vein thrombosis was a patient in the 6th decade and had malignancy. Deep vein thrombosis occured due to risk factors such as immobilisation, pregnancy, postpartum period or maligancy in 6 patients. Femoral veins were involved in all patients with factor V leiden mutation. Conclusion: Life time oral anticoagulation therapy is inevitable in patients with Factor 5 leiden mutation especially with recurrent deep vein thrombosis. Additionally; screening tests for family members must be considered. In patients with high risk, genetic consultation is important for prophylaxis of deep vein thrombosis and preparation for medical emergencies. Keywords : Factor V leiden; thromboembolism; deep venous thrombosis; prophylaxis
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