Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080



Turkish Journal of Vascular Surgery 2015 , Vol 24 , Issue 3
Clopidogrel Loading or Maintenance Before Carotid Endarterectomy is Not Risky for Post-operative Bleeding orWound Revision
Mehmet Kerem KARACA1, Özden VEZİR1, Murat ÖZEREN1, Barlas Naim AYTAÇOĞLU1, Caner BOZALİ2, Bilal YILMAZ2, Nehir SUCU1
1Department of Cardiovascular Surgery, Mersin University Faculty of Medicine, Mersin
2Clinic of Cardiovascular Surgery, Mersin State Hospital, Mersin
DOI : 10.9739/uvcd.2015-47488 Objective: To investigate whether clopidogrel loading or maintenance before carotid endarterec-tomy affecs postoperative bleeding or wound revision. Material and Methods: Patients with symptomatic carotid arterial disease were divided into 3 groups: group I was not on antithrombotic therapy, group II was on clopidogrel and antithrombotic therapy for at least 7 days, and group III was on antithrombotic therapy without clopidogrel and administered 600 mg clopidogrel 2 h before surgery. Results: Hemoglobin decreased in all groups. The differences between preoperative and postopera-tive values were statistically significant. Hematoma developed in a total of 4 patients; 2 of them were in group II, and 2 were in group III. No difference was found among the groups in terms of bleeding-related complications. Conclusion: Insignificant hemorrhage-related complications support administration of a loading dose of clopidogrel together with the ongoing anticoagulant- antiaggregant therapy before carotid endarterectomy. Keywords : Endarterectomy, carotid; clopidogrel; hematoma; hemorrhage
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