¹Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara DOI : 10.9739/uvcd.2014-40474 Despite improvements in medical technologies, there is still not a holistic approach to lymphatic disorders. However, secondary lymphedema is a preventable form of lymphatic disorders by its association with the underlying etiology. Thus, it is easier to prevent than cure. In this report, we present a patient admitted to our clinic with an interesting traumatic lymphedema secondary to accidental injection of tilmicosin phosphate, which is often used as macrolide antibiotic in veterinary practice. Keywords : Lymphedema; macrolides; necrosis; fibrosis