Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Damar Cer Derg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 1301 - 1839 E-ISSN 2149 - 1259


Turkish Journal of Vascular Surgery 2002 , Vol 11 , Issue 1
THE RO LE OF ASCORBID ACID ON REDUCING RENAL INJURY DUE TO TRANSIENT ABDOMINAL AORTIC OCCLUSION IN RATS
Özal Berkan1, Esin Yıldız2, Semih Ayan3, Gökhaıı Gökçe3, Hakan Kılıçaslan3, İlhan Günay1, Kasım Doğan 1
1Ankara Üniversitesi Tıp Fakültesi Radiodiagııostik Anabilinı Dalı, Ankara Objecti ve: The aim of this study was to investigate renal injury due to ischemia/reperfusion (1/R) after transient acu­ te distal abdominal aortic occlusion and ta evaluate the effect of ascorbic acid on these alterations.

Material and Method: Nineteen rats were divided into three groups. Rats in the control group (Group 1) were under­ taken laparotomy and closed after exploration of abdominal aorta. in the I/R group (Group 2), the infrarenal aorta of the rats were clamped tora period of 3 hours. After the ischemic period, aortic clamping was removed and waited tor 1 hour of reperfusion period. The rats in the ascorbic acid group (Group 3) were administered sodium ascorbic acid commencing !rom 5 days before experimental procedure. The animals were sacrificed and the histological specimens of the lungs were examined. The pathological changes in the lungs were ranged between stage O+ and 4 correlate d to the level of increasing injury.

Result: Edema, congestion and hydropic degeneration were more prominent in the specimens of group 2 and 3 as compared to the control group. The average scores were 0.6, 2.14, 1.85 in the groups 1,2,3, respectively. Group 3 was associated with lesser degrees of renal injury as compared ta the second group (p<0.05).

Conclusions: Pretreatment with ascorbic acid was beneficial in prevention of renal injury due to ischemia/reperfu­ sion after transient acute distal abdominal aortic occlusion Keywords : Ascorbic acid, renal injury, aortic occlusion, ischemia reperfusion