Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Damar Cer Derg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 1301 - 1839 E-ISSN 2149 - 1259

Turkish Journal of Vascular Surgery 0 , Vol 0 , Issue 0
The evaluation of C-reactive protein values in patients with primary chronic venous insufficiency
Burak Açıkgöz1, Ali Aycan Kavala1, Saygın Türkyılmaz, Yusuf Kuserli
1Department of Cardiovascular Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey DOI : 10.9739/tjvs.2019.219 Objectives: The aim of our study was to assess the alterations in serum C-reactive protein (CRP) values in patients with chronic venous insufficiency (CVI).

Patients and methods: Between June 2013 and November 2013, a total of 100 consecutive patients (50 males, 50 females; mean age 42±13 years; range, 21 to 61 years) who were admitted to the outpatient clinic with pain, prickle, paresthesia or night cramps were included in this study. The patients were divided into two groups. Varice group (n=50) consisted of isolated CVI patients (primary CVI) with a family history of varices and without a history of deep venous thrombosis. Non-varice group (n=50) consisted of patients who underwent non-venous pathologies-related surgical interventions previously or had no prior history of surgery. All patients underwent lower limb venous Duplex ultrasound examination bilaterally. Serum CRP and complete blood count examinations were performed and white blood cell (WBC) levels were assessed.

Results: There was no statistically significant difference between the varice group and non-varice group in terms of the mean CRP values (3.80±1.47 mg/L vs 4.74±3.86 mg/L, respectively; p=0.983). However, the mean WBC levels were statistically and significantly different between the groups (6966±1943/μL for varice group vs 8528±2767/μL for non-varice group, respectively; p<0.05).

Conclusion: Our study results suggest that CRP is not a valuable marker in the diagnosis of primary CVI. Keywords : C-Reactive protein; inflammation; varice; venous insufficiency