Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080


Turkish Journal of Vascular Surgery 0 , Vol 0 , Issue 0
Methylenetetrahydrofolate reductase polymorphisms in acute deep vein thrombosis
Sefa Şenol1, Kürşat Kargün2
1Department of Cardiovascular Surgery, Fethi Sekin Elazığ Training and Research Hospital, Elazığ, Turkey
2Fırat University Institute of Health Sciences, Elazığ, Turkey
DOI : 10.9739/tjvs.2019.352 Objectives: In this study, we aimed to investigate the effectiveness of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms in acute deep vein thrombosis (DVT).

Patients and methods: Between January 2017 and May 2018, a total of 64 patients (37 males, 27 females; mean age 35±18 years; range 19 to 59 years) who were followed with the diagnosis of acute DVT and 64 healthy controls (35 males, 29 females; mean age 43±14 years; range 23 to 57 years) without any vascular pathology were included. The MTHFR C677T and A1298C gene polymorphisms of the samples were identified using the real-time polymerase chain reaction.

Results: There was no statistically significant difference in the polymorphisms and allele frequencies of the MTHFR C677T and A1298C genes between the patient and control groups (p>0.05).

Conclusion: In this study, the MTHFR C677T and A1298C gene polymorphisms were not found to be risk factors for acute DVT. Keywords : Acute deep vein thrombosis; gene polymorphism; methylenetetrahydrofolate reductase