Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080



Turkish Journal of Vascular Surgery 2004 , Vol 13 , Issue 3
EFFECS OF INSUFFICIENCY IN SAPHENOUS VEIN ON ANTIOXIDANT SYSTEM
Barlas Naim AYTAÇOĞLU1, Nehir SUCU1, Lülüfer TAMER2, Murat ÖZEREN1, İlhan MAVİOĞLU1, Özgün BAYRI1, Orhan GÜNGÖR1, Murat DİKMENGİL1
1Mersin Üniversitesi, Tıp Fakültesi, Kalp ve Damar Cerrahisi, AD, Mersin
2Mersin Üniversitesi, Tıp Fakültesi, Biyokimya AD, Mersin
Objective: In this study, we aimed to investigate the effect of the insufficiency in vena saphena magna (VSM) on the non-enzymatic anti-oxidant system.

Methods: Sixty-seven patients who admitted to the outpatient ward of our clinic with complaints of varicose veins were included into the study. The study group consisted of 30 patients who had significant insufficiency in the VSM. Patients without insufficiency in VSM constituted the control group. Blood samples were collected from the dorsal veins of the affected extremities. Malondialdehyde, erythrocyte reduced glutathione, Vitamin C and Vitamin E were the parameters analyzed.

Results: In the study group, MDA levels were found to be significantly higher than the control group (p=0.001). GSH, vitamin C and vitamin E levels were significantly lower in the same group when compared with the control group (p=0.05, p=0.03, p=0.001).

Conclusion: In patients with significant regurgitation in VSM, there is a reduction in the anti-oxidant systems. Addition of vitamin C and E, as anti-oxidants, to the current known management for the insufficiencies of the VSM will fairly complete the missing part in medical therapy. (Turkish J Vasc Surg 2004;13(3):13-16). Keywords : Varicose veins, anti-oxidant system

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