Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society E-ISSN 2667-5080

Turkish Journal of Vascular Surgery 2021 , Vol 30 , Issue 2
The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping
Ozan Karakişi1, Doğuş Hemşinli1, Levent Tümkaya2, Şaban Ergene1, Tolga Mercantepe2, Adnan Yılmaz3
1Department of Cardiovascular Surgery, Recep Tayyip Erdoğan University, Medical Faculty, Rize, Turkey
2Department of Histology and Embryology, Recep Tayyip Erdoğan University Medical Faculty, Rize, Turkey
3Department of Medical Biochemistry, Recep Tayyip Erdoğan University Medical Faculty, Rize, Turkey
DOI : 10.9739/tjvs.2021.986 Objectives: This study aims to examine the potential protective effect of the selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) against aortic occlusion-induced myocardial injury.

Patients and methods: A total of 30 rats were randomly assigned into three groups of 10 animals each as control, ischemia+reperfusion (I/Rep), and I/Rep+DEX. In the I/Rep and I/Rep+DEX groups, after the completion of the shock stage, 60-min lower torso ischemia was induced with the application of cross-clamps to the abdominal aorta, followed by 120-min reperfusion. The I/Rep+DEX group received intraperitoneal 100 μg/kg DEX 30 min before the ischemia period.

Results: Malondialdehyde (MDA) levels in myocardial tissue increased with the application of I/Rep, while glutathione (GSH) levels decreased. We also observed swollen, degenerative, apoptotic cardiac myofibrils exhibiting caspase-3 positivity, widespread edematous areas, vascular congestion, and an increase in the heart damage scores. The MDA levels decreased with DEX administration, while the GSH levels increased. Degenerative, apoptotic cardiac myofibrils exhibiting loss of cytoplasm content, and vascular congestion also decreased.

Conclusion: Our study results suggest that DEX may have a future role in the treatment of myocardial damage occurring due to reperfusion, following ruptured abdominal aortic aneurysm surgery. Keywords : Abdominal aortic aneurysm, dexmedetomidine, myocardium, oxidative stress, reperfusion

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