Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society ISSN 2667-4947 E-ISSN 2667-5080



Turkish Journal of Vascular Surgery 2004 , Vol 13 , Issue 3
THE VASCULAR TOXİCİTY DUE TO GEMCİTABİNE THERAPY AND İTS MANAGEMENT WİTH CERVİCAL SYMPATHETİC BLOCKAGE
Nezihi KÜÇÜKARSLAN1, Adem GÜLER1, Sibel POÇAN2, Melih Hulusi US1, Mutasım SÜNGÜN1, Yücesin ARSLAN1, Ahmet Turan YILMAZ1
1GATA Haydarpaşa Eğitim Hastanesi, Kalp ve Damar Cerrahi Servisi, Kadıköy, İstanbul
2GATA Haydarpaşa Eğitim Hastanesi, Anestezi Servisi, Kadıköy, İstanbul
Gemcitabine is a nucleocid analogue used commonly for chemotherapy of solid tumours. One of its common side effects is vascular toxicity. Case due to Gemcitabine therapy is an uretereal carcinoma. The patient admitted with muscle pain in upper extremity finger with movement, sensitiveness, hypoestesia, palor, and cyanosis on the second cure of Gemcitabine treatment. Microangiopathy due to Gemcitabine was diagnosed and vasodilatation and ten cures of servical sympathetic blockage were applied. Following the treatment sign and symptoms disappeared dramatically. In regard of this case we believe that servical sympathetic blokage is valuable as surgical sympathectomy in early stages of microangiopathy due to Gemcitabine. (Turkish J Vasc Surg 2004;13(3):39-42). Keywords : Microangiopathy; chemotherapy; Gemcitabine; sympathetic blockage
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