Editor-in-Chief Ufuk Demirkılıç Frequency Quarterly Abbreviation Turk J Vasc Surg Publisher Turkish National Vascular and Endovascular Surgery Society E-ISSN 2667-5080

Turkish Journal of Vascular Surgery 2002 , Vol 11 , Issue 2
Ufuk Yetkin1, Özalp Karabay2, Mert Kestelli1
1Atatürk Eğitim ve Araştır m a Hastanesi Kalp ve Damar Cerrahisi Kliniği, İzmir
2Alsancak Devlet Hastanesi Kalp ve Damar Cerrahisi Uzmanı, İzmir
Purpose: Studies about prostaglandin metabolism, microcirculation and role of endothelial cells in recent years inc­ reased our understanding lor Raynaud phenomenon pathophysiology and new therapy modalities could developed.

Material and Method: Sixty patients with primary Raynaud phenomenon, admitted to our outpatient clinics between 1999 and 2001, divided to three groups. We applied conservative precautions to all cases (cessation of smoking, pre­ vention from cold ete.). Also nifedipin + aspirin + pentoxyphillin protocol had been used in Group 1, prazo s in w as ad ­ d ed to this protocol in Group il and in Group 111 i nste ad of prazosin, nitroglycerin TTS bands were used. Cases were followed monthly and at sixth month they were evaluated with anamnestic subjective symptoms and cold water stress tesis.

Results: After applying therapy protocols in 43 of 60 cases we determined total anamnestic improvement (Group il had the highest rate, 80%) and in 40 cases (66,6%) initial cold water stress test's pathological result returned to nor­ mal (Group il had the highest rate). Therapy results are betler with calcium channel blockers and combining them with prazosin or nitroglycerin increase the paliative result rates with a synergistic effect. Keywords : Raynaud Phenomenon, treatement, nifedipin

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