THE EFFECT OF TRIMETAZIDINE iN EXPERIMENTAL RENAL ISCHEMIA-REPERFUSION

The effect of ischemia reperfusion on kidneys, tissue malondialdehyde (MDA) concentration, Gluthatıon Peroxidase (GSH-Px) and Superoxide Dismutase (SOO) activities were measured in 20 rats subject to occlusıon of the lef! re­ anal artery for 60 min followed by 24 hours reperfusıon. The animals were separated in two equal groups: Group 1 (control) and Group il (TMZ). A right nephrectomy was performed at the beginning of the ischemic period for control on each groups. After 24 h, tissue samples were taken for histopathological and biochemically examination. After 24 h of reperfusion, the MDA levels significantly increased (Group 1: p<0.001 and Group il: p<0.01, respecti­ vely), but the MDA levels in the Group I were found to be significantly elevated when compared with the Group il (P<0.01). GSH-Px and SOD activity significantly decreased in the Group 1 (p<0.05). SOD and GSH-P•x activity chan­ ges of the Group il were not meaningfull. The TMZ group had a acut tubuler necrosis grade of 1.5 which was signi­ ficantly lower than in group 1 (p<0.01).

It is suggested that TMZ is a useful protective agent of renal damage from oxygen free radicals.