THE ROLE OF ISCHEMIC PRECONDITIONING ON REDUCING ORGAN INJURY DUE TO TRANSIENT ABDOMINAL AORTIC OCCLUSION

Materials and method: Seventeen rats were divided into 3 groups as control (Group 1), I/R group (Group 2) and ischemic preconditioning. Rats in the group 1 were undertaken laparotomy and exploration of abdominal aorta and closed after 4 hours. In the second group, the infrarenal aorta of the rats were clamped a period of 3 hours. After ischemic period, aortic clamping was removed and waited for 1 hour of reperfusion period. In IPC group, after ischemia/reperfusion periods of 5 minutes which were repeated 3 times, an ischemia period for 2 hour and 45 minutes and a subsequent reperfusion for 1 hour were maintained. The animals were sacrificed and the histological specimens of the lungs, liver and kidneys were examined at the end of procedure.

Results: The injury performance score was found to be significantly higher in the lungs of IPC group than those I/R group (p<0.05). That was also accurate for the liver, but it was statistically insignificant (p>0.05). In renal tissue, performance score was lower in the IPC group, but it was not significant as compared to I/R group (p>0.05).

Conclusion: The results of this study suggested that IPC contributed the increase of injury after ischemia/reperfusion in the liver and especially in the lungs. Contrary to these, it was found to be slightly beneficial in the kidney after I/R. (Turkish J Vasc Surg 2005;14(3):15-20).