Semptomatik ve Asemptomatik Hastalarda Karotid Arter Aterom Plak İçeriğinin Karşılaştırılması

Objective: Homocystein, von Willebrand factor (vWF), fibrin and C-reactive protein (CRP) values were measured in carotid artery plaques from symptomatic and asymptomatic patients with carotid stenosis. The values were evaluated between groups. Material and Methods: 36 patients who underwent carotid endarterectomy, aged 54 to 77 (mean age: 64.16, 23 male, 13 female) were included in the study. 20 of them were symptomatic, 16 asymptomatic. Homocystein, fibrin, vWF, CRP were measured from samples taken from carotid plaques converted into supernatant. SPSS for Windows 10.0 programme was used for statistical analysis. P value less than 0.05 was accepted significant. Results: Homocystein value in symptomatic patients was 4.036±1.19 μmol/L, in asymptomatic patients, was 3.647±0.772 μmol/L (p=0.519). Fibrin value in symptomatic patients was 227.54±38.81 mg/dl, in asymptomatic patients, was 88.26±5.93 mg/dl (p<0.001). vWF in symptomatic group was 59.33%± 9.13%, in asymptomatics, was 42.83%±5.33% (p<0.001). CRP in symptomatic group was 0.33±0.13 mg/dl, in asymptomatics, was 0.26± 0.091 mg/dl (p=0.033). Differences in parameters, except for homocystein, were statistically significant. Conclusion: There was no relation between homocystein level an symptomatology. Amount of fibrin in the carotid artery atherosclerotic plaques increases with hemorrhage that may cause critical stenosis and disrupt plaque and so cause microemboli. Modification of the mentioned factors can change the progress of the disease.