The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping
Ozan Karakişi, Doğuş Hemşinli, Levent Tümkaya, Şaban Ergene, Tolga Mercantepe, Adnan Yılmaz
DOI: 10.9739/tjvs.2021.986 · Page: 93-101 · 105 Views · 6 Downloads · 0 Citations
Abstract
Results: Malondialdehyde (MDA) levels in myocardial tissue increased with the application of I/Rep, while glutathione (GSH) levels decreased. We also observed swollen, degenerative, apoptotic cardiac myofibrils exhibiting caspase-3 positivity, widespread edematous areas, vascular congestion, and an increase in the heart damage scores. The MDA levels decreased with DEX administration, while the GSH levels increased. Degenerative, apoptotic cardiac myofibrils exhibiting loss of cytoplasm content, and vascular congestion also decreased.
Conclusion: Our study results suggest that DEX may have a future role in the treatment of myocardial damage occurring due to reperfusion, following ruptured abdominal aortic aneurysm surgery.
Keywords : Abdominal aortic aneurysm, dexmedetomidine, myocardium, oxidative stress, reperfusion
Keywords : Abdominal aortic aneurysm; dexmedetomidine; myocardium; oxidative stress; reperfusion