Cell Therapy for Peripheral Arterial Disease: Cellular and Molecular Aspect

The aim of this review is to define the cell based therapy applications, together with revision of up to date literature in peripheral artery diseases, predominantly, the possible mecha- nisms of the theraupetic effect regarding the experimental studies. Clinical studies about this issue will be mentioned limitedly. The issue titles which must be answered by the angiogenesis studies which are targeted by the cell based therapies will also be mentioned throughout this paper. The term regenerative medicine refers to the strategies and methodologies used in curing conditions as opposed to treating them. Despite more than 10 years of worldwide activity on adult stem cell de- velopmental plasticity (metamoirosis), current results of fundamental research are still in the em- bryonic stage. Cardiovascular disorders are the leading causes of mortality and morbidity in the developed world. Cell-based modalities have received considerable scientific attention over the last decade for their potential use in this clinical arena. The question, whether or not future improve- ments on cell-based therapies will provide remarkable improvement in survival and quality of life for millions of patients with cardiovascular disorders still remains unsolved.