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Year : 2019, Volume : 28, Issue : 1

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  3. Year : 2019, Volume : 28, Issue : 1

Serum SCUBE-1 levels can predict endothelial dysfunction in healthy young adults

Oğuz Karahan, Mustafa Etli̇

DOI: 10.9739/tjvs.2019.299 · Page: 031-035 · 127 Views · 7 Downloads · 2 Citations

Abstract

Objectives: This study aims to investigate the predictive role of the signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1) in the presence of endothelial dysfunction.

Patients and methods: Between December 2014 and August 2015, 120 healthy young adults (68 males, 52 females; mean age 29.7±4.1 years; range, 20 to 35 years) without a previous history of cardiovascular disease were included. The participants were divided into two groups according to normal (n=73) and abnormal flow-mediated dilatation (FMD) response (n=47). Simultaneously, the standard biochemical markers, blood urea-nitrogen, creatinine, liver enzymes, glucose, lipids and SCUBE-1 levels were determined from the blood samples.

Results: Multivariable logistic regression revealed a strong association between SCUBE-1 and FMD (p<0.001). We found that for a cut-off point of >136.37 ng/mL, SCUBE-1 had 85.0% sensitivity and 81.2% specificity to identify abnormal FMD.

Conclusion: Our study findings indicate that there is a favorable inverse correlation between the SCUBE-1 and FMD.

Keywords : Atherosclerosis progression; endothelial dysfunction; flow-mediated vasodilatation; SCUBE-1.

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