The effect of deep venous thrombosis on oxidative damage and vitamin A and beta-carotene levels

Patients and methods: A total of 50 DVT patients (29 females, 21 males; mean age 48 years; range, 20 to 75 years) who were admitted to the cardiovascular surgery clinic of Elazığ Training and Research Hospital with acute (<2 weeks) or chronic (≥4 weeks) DVT and 100 healthy individuals (54 females, 46 males; mean age 46 years; range, 16 to 69 years) between January 2018 and July 2018 were included. Malondialdehyde, vitamin A, and beta-carotene levels in plasma of peripheral blood samples were analyzed.

Results: Demographic characteristics of the acute and chronic DVT patients were similar (p>0.05). In all DVT patients having thrombosis in the distal and proximal leg veins, the mean malondialdehyde (MDA) levels significantly increased and the mean levels of vitamin A significantly decreased, compared to healthy controls (p<0.05). No significant difference was found in vitamin A levels and demographic characteristics between acute and chronic DVT patients (p>0.05).

Conclusion: Our study results suggest that decreased vitamin A levels may play a role in the development of DVT.